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Tablet manufacturing process by dry granulation

Tablet manufacturing process by dry granulation


Tablet manufacturing process by dry granulation In case of dry granulation, first of all, API and excipients in suitable quantity are dispensed. After the dispensing process, API and intragranular excipients are subjected to mixing process (dry mixing/blending) What is intragranular excipients? They are the excipients added in the granules. They are called as intragranular excipients These excipients (intragranular) and API are the part of the granules and some excipients are added extragranularly After dry mixing process Materials are subjected to roller compaction to prepare slugs These slugs are prepared under roller compactor Here, annotations are viewable on desktop computer or desktop site of your mobile devices. After that, these slugs are subject to milling and crushing process to prepare required size of the granules The granule size may be about to # 16 to # 30 or any other suitable size of the sieve can be selected depending upon the requirement of the product These granules are subjected to mixing process with extragranular excipients Extragranular excipients are those excipients, that we add after granulation So they are not the part of the granules They may be extragranular diluent, disintegrating agents, or any other suitable material After that the material is subjected to lubrication process with lubricating agents Lubricating agents such as magnesium stearate, calcium stearate or stearic acid or depending upon requirement of the product any other suitable lubricating agents can be utilized. This is the process of dry granulation Difference with the wet granulation is that here there is no wet granulation, completely dry process, no use of granulating liquid, so drying step is omitted. So that, this process is cost effective.

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